Frequently given for premenstrual syndrome symptoms and for symptoms that are suspected to be menopausal in origin. PMS symptoms will frequently respond, to an extent, to progesterone therapy since progesterone can affect body temperature patterns as can thyroid hormones. Frequently, however, the symptoms will not thoroughly respond to progesterone therapy and do not often remain persistently improved after that therapy is discontinued. One major difficulty with female hormone therapy is that there are a great number of variables to be considered. Usually, the greater the number of variables, the more complicated and the less predictable a certain treatment is. For example, it would be hard to direct therapy, since the female hormone system has a cyclical (monthly) influence on the body temperature pattern and it would be hard to predict when it should go up and when it should go down. And, there are both progesterones and estrogens which can be given in many different combinations and it is hard to predict what influence those combinations will have. There are also many different brands and forms of estrogens and progesterones, some of which are not found in nature. When the symptoms return after the progesterone therapy has been discontinued (even if the symptoms were improved with progesterone therapy), it makes it more likely that the treatment was affecting the symptoms rather than the underlying problem. PMS resulting from Wilson’s Temperature Syndrome will frequently remain improved even after treatment has been discontinued.