Patients are frequently treated with long lists of different headache medicines for the troublesome and debilitating headaches, and even severe migraines that can be associated with Wilson’s Temperature Syndrome. These medicines include aspirin, acetaminophen, ibuprofen, and an assortment of migraine headache medicines (beta-blockers, calcium channel-blockers, ergotamines, and narcotic pain medicines). One dramatic case that I remember involved a woman who was diagnosed as having severe basilar artery migraine headaches that would cause severe headache pain, nausea and vomiting, and even neurological changes that would cause numbness and/or weakness of her face, mouth, and hands. Her migraines were so severe at times they would leave her almost unresponsive. During such episodes she would often be taken to the hospital and given oxygen therapy which would sometimes help. Since her headaches were so frequent and so severe, she actually was given a prescription for oxygen tanks that she could keep at home for this purpose. When the migraine headaches became very severe she would sometimes use oxygen at home to provide her brain with sufficient oxygen. She has undergone every available migraine headache treatment from pain medicines, to the blood pressure medicines that are frequently used for migraine headaches (beta-blockers and calcium channel-blockers). She has even been given an experimental treatment involving a blood thinner. She was given a treatment wherein a blood thinner was aerosolized into a fine mist which she would then inhale in an attempt to alleviate the migraines. This treatment would help but it would not correct her severe migraine headaches. To the patient’s utter dismay her migraine headaches responded quickly and dramatically to proper thyroid hormone treatment and body temperature pattern normalization. She has not had a severe headache since the time she was started on thyroid hormone therapy, when she was to the point of having these headaches every several days if not every day. Not only has she not had a severe headache but she hasn’t had any (other than those easily relieved with very mild analgesic medicine, such as aspirin). In this patient’s case, and in many others, the thyroid hormone treatment wasn’t just helpful in the treatment of migraines — but essentially eliminated them.