Wilson’s Temperature Syndrome patients often benefit from marriage and family counseling for the interpersonal relationship problems that can sometimes result due to the symptoms of MED caused by low body temperature patterns. However, this counseling can sometimes be disappointing in that it cannot always get to the underlying problem. I have seen cases where proper thyroid hormone treatment resulted in such an improved level of well-being and restored emotional resources that the patient and patient’s family were able to enjoy much more appropriate interpersonal relationships-so much so that the need for marriage and family counseling was obviated. It is truly amazing to see how much Multiple Enzyme Dysfunction resulting from low body temperature patterns caused by Wilson’s Temperature Syndrome can affect the attitudes of people, the way they feel about themselves and other people, and the way they interact and get along with other people. It can literally be as great as the difference between night and day.