This is your first clue that the patient may be a one-day compensator (p91). Such patients’ negative-feedback inhibition of the pituitary gland may be so rapid that the patients can actually over-compensate, such that their temperatures can temporarily go lower than they were prior to T3 therapy. Such patients’ symptoms can worsen at such a time as well. These patients are more likely to experience side effects of unsteadiness from the T3 therapy than others are. It is more difficult to keep the T3 levels steady of such patients, and so extra care should be taken to keep T3 levels as steady as possible from the start. If the patient’s T3 levels become too destabilized to proceed with the T3 therapy, the patient should be weaned off the therapy. The pros and cons of the T3 therapy should be reconsidered in light of the likelihood that the patient is a one-day compensator. If the T3 therapy is re-initiated, the patient’s T3 levels should first be allowed to steady down very well by keeping the patient off T3 for from 5 – 14 days. And the T3 therapy should be increased rapidly enough to take deliberate exogenous control of the thyroid system to make the transition of control as smooth as possible. If not, perhaps the one-day compensator would be better off not taking the T3 therapy at all. Remember- it is important that everything be done gradually, but not necessarily slowly.