If patients’ temperatures begin to drop right away as soon as they start weaning, then it is likely that the T3 therapy is being weaned too quickly (c12). What if the patient is able to wean down several decrements, without a drop in temperature but cannot go below a certain level without the temperature dropping? In that case, it may be that the patient does not have a sufficient supply of endogenous or exogenous T4 available for conversion to T3 to maintain the present level of thyroid stimulation to the cells (the patient may be hypothyroid, see c11). What if the patient is able to wean all the way off the cycle and stay well for a period of days before the symptoms return? That suggests that the patient was almost able to maintain well off the treatment and might not have because the treatment was weaned just a little too quickly. Or the worsening of the symptoms again may be due to an actual relapse due to some precipitating factor (such as a big stress). On the other hand, what if the patient’s temperature and symptoms worsen as the T3 is being weaned even though it is being weaned slowly enough and there is a sufficient supply of T4 for conversion to T3? This suggests that there may be some unaddressed factor(s) that are preventing the patient from staying improved (e.g., continuing stress). If the patient is not under a lot of stress, then some other factor may be preventing the improvement on T3 therapy to persist after the treatment has been discontinued. In such cases, one might consider adjusting some other medicines a patient may be taking (such as female hormones), and look to see what other changes can be made in other areas (p105, Q10, Q29).