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Dr. Denton’s Comments

“Now 8 and a half years later it is an integral part of my practice”

-Sandra Denton, MD

Anchorage, AK

Issues covered in the account below:

  • Resetting the Thyroid system
  • Chronic Fatigue Syndrome
  • Thyroid tests
  • Sustained release T3
  • Classic hypothyroid symptoms
  • Compounding pharmacies

I have been using time release liothyronine for at least 8 1/2 years and have been extremely pleased with the results. Although giving instructions and finding the optimal dose can be a bit time-consuming initially, the rewards of seeing the often-dramatic improvements in the patient are well worth the effort. Although I use a lot of T3/T4 combination therapy with various natural thyroid preparations with good success and resolution of many low thyroid symptoms, I’m not able to discontinue the therapy as I often am using the time release form of T3. It my opinion, the major advantage of Wilson’s Temperature Syndrome is to ” reset” the system to work on its own instead of taking over the work of the thyroid gland and having to take medication the rest of your life.

In our practice after getting the thyroid condition stable, we focus on determining the possible cause of damage to the thyroid system, such as Epstein Barton or Cytomegalo virus, Mycoplasma infections, radiation exposure, or mercury from dental fillings, etc. In such cases, our patients are able to discontinue thyroid therapy more quickly and regain their health when an underlying cause has been corrected. Each provider has a different approach to treating these conditions weather it be with antibiotics, anti-virals, and chelating agents to remove heavy metals along with the removal of toxic dental materials, thus enabling the thyroid gland (as well as the rest of the body) to repair and heal.

I was attracted to investigate Wilson’s Temperature Syndrome and therapy with time release T3 because of the stories a trusted colleague in Colorado Springs kept telling me. He even suggested it might be beneficial in treating my own Chronic Fatigue Syndrome. Because of classic hypothyroid symptoms, I had had numerous thyroid tests performed, all of which had been “normal.” When indeed it was a crucial key in my own recovery, I started using it with my patients. Now 8 1/2 years later it is an integral part of my practice. Patients come to me by word of mouth from satisfied patients. After reading the book or logging onto the Wilson’s Temperature Syndrome web site, they are eager to get started on “something that seems to be the first thing that makes sense in a long time.” I find it extremely important for the patient to be educated as much as possible and this often increases their motivation to comply with the somewhat complicated instructions.

I have also found some differences between compounding pharmacies and how they prepare the T3. One pharmacist expressed surprise when I explained to him the time release factor was supposed to be for 12 hours. He had been using a different grade of methycellulose and it was only 8 hours. Another pharmacist insisted on putting dye in the T3 and others insist on putting the T3 in color capsules to differentiate doses. This is not good for my allergic patients and may explain why some doctors are not getting the desired results with their patients on Wilson Thyroid Syndrome treatment.

About the Author:

Denis Wilson, MD described Wilson 's Temperature Syndrome in 1988 after observing people with symptoms of low thyroid and low body temperature, yet who had normal blood tests. He found that by normalizing their temperatures with T3 (without T4) their symptoms often remained improved even after the treatment was discontinued. He was the first doctor to use sustained-release T3.


  1. Helen Feldman May 10, 2013 at 5:32 pm - Reply

    I know that your protocol works on most people. But after two years, I was not able to stabilize. My doctor was in touch with your help line frequently. I have the MTHRFR mutation (heterozygous), and wonder if this had anything to do with it. I wrote you about this problem before, but I received no comment from you. It would be nice to get one. I don’t know if I should try again. Thank you.
    Helen Feldman

    • Dr. Denis Wilson May 13, 2013 at 5:19 am - Reply

      I’m sorry to say, but I’m not sure how the MTHFR gene affects the T3 therapy. Best wishes

  2. ann robison May 22, 2013 at 9:03 pm - Reply

    How do I order a thermometer? I don’t see anything about it on your website….

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