You can take thyroid medicine and have normal blood tests and still have a low body temperature and classic symptoms. Body temperature is what correlates the best with the symptoms. Therefore, thyroid system evaluation or management that does not take body temperature patterns into account is misdirected and often ineffective. Chapter 12 of the Doctor’s Manual is devoted to explaining the treatment and management of patients who are not doing well on T4-containing medicine. As it turns out, patients who have hypothyroidism (low thyroid gland function) may also be suffering from Wilson’s Temperature Syndrome. And if the Wilson’s Temperature Syndrome is left untreated those patients will continue to experience troublesome symptoms.