Increasing the dose of T3 every three days or longer is tolerated well by 9 patients out of 10. Most patients tolerate the dose being increased every three days very well. However, about 10% of patients are one-day compensators that are likely to tolerate one-day increases better. Slow compensators usually tolerate rapid increases much better than rapid compensators tolerate slow ones. It is easier to prevent people from becoming management problems than it is to stop them from being management problems once they are.