Patients are much more likely to need less medicine on subsequent cycles, if their temperatures are captured on previous ones. If it’s the first dosage increment, and the patient hasn’t “compensated” before, then you may have to wait 3 weeks to see if the patient is going to compensate, because if the patients haven’t compensated within about 3 weeks, they’re probably not going to compensate. If this is not the first dosage increase of the first cycle, and the patient has compensated before, then you can wait to see if the patient will compensate again in about that same time period. If the patient does not compensate back down, then the patient’s temperature has been “captured”.