When a patient retains a net (albeit subtotal) clinical improvement from a cycle of T3 therapy, that is the first strong indication that the therapeutic trial of T3 therapy has been a success. At that point, it becomes quite likely that the patient has “made it over the hump,” and has a good chance of being able to retain more and more net improvement as the cycling process continues. This is especially possible if the patient is not under tremendous stress, and can employ reasonably good habits of diet, exercise, sleep, etc.