Some of the most gratifying symptoms to treat include migraines, PMS, panic attacks, and depression. These symptoms have two things in common. First, they are among the most debilitating of complaints, and secondly, they are among the most typically responsive to T3 therapy. On the other hand, other symptoms are less predictably responsive. For example, it’s harder to predict who might enjoy relief from the disturbing complaint of easy weight gain, and who will not. For instance, in some cases patients may experience an appreciable weight gain together with the onset of many other symptoms of Wilson’s Temperature Syndrome, after a major stress. And with treatment all of those symptoms may resolve, while the weight remains. In such cases, the patients are often perplexed. They wonder why the weight didn’t normalize with the other symptoms, when it clearly came on with them. I personally feel that part of the explanation for this phenomenon has to do with the change in a patient’s surface area to volume ratio which is an issue discussed in the book: Wilson’s Temperature Syndrome – A Reversible Thyroid Problem. At any rate, it is clear that weight is a multi-faceted issue that depends on a number of factors such as diet and exercise, among others. These observations suggest that the symptoms that are the most predictably responsive depend on factors that are the most directly influenced by body temperature patterns.