Wilson’s Temperature Syndrome patients are sometimes treated with cortisone for arthritis, asthma, and hair loss. Low body temperature patterns frequently can lead to fluid retention or swelling that can result in aches and pains of the muscles and joints; for which patients are sometimes treated with cortisone. It is interesting that cortisone is well known to inhibit 5′-deiodinase (the enzyme that converts T4 to T3) directly. Understandably then, cortisone therapy has been seen to precipitate or bring on cases of Wilson’s Temperature Syndrome as well as worsen existing cases. Cortisone therapy can often be quite useful in the treatment of arthritis, asthma, and hair loss (frequently given by injection into the scalp). However, sometimes these problems can respond much better to thyroid hormone therapy than to cortisone therapy as can the other related symptoms of Wilson’s Temperature Syndrome. Careful history can frequently correlate the onset of these symptoms with the clinical picture of Wilson’s Temperature Syndrome (beginning after a major stress, associated with low body temperature patterns, and responding very well with normalization of the body temperature patterns).